Key Publications:

 

In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats Francisco R. López-Picón1, Anna K. Kirjavainen, Sarita Forsback, Jatta S. Takkinen, Dan Peters, Merja Haaparanta-Solin, Olof Solin. Theranostics 2019; 9(1):11-19

Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand. Magnussen JH, Ettrup A, Donat CK, Peters D, Pedersen MH, Knudsen GM, Mikkelsen JD. Eur J Pharmacol. 2015 Sep 5;762:35-41.

 

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [(18)F]NS14490. Rötering S, Deuther-Conrad W, Cumming P, Donat CK, Scheunemann M, Fischer S, Xiong G, Steinbach J, Peters D, Sabri O, Bucerius J, Brust P. EJNMMI Res. 2014 Aug 5;4:43.

 

Development of radioligands for the imaging of  alpha7 nicotinic acetylcholine receptors with positron emission tomography. Brust, Peter; Peters Dan; Deuther-Conrad, Winnie. Current Drug Targets (2012), 13(5), 594-601.

 

[11C]NS14492 as a novel radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. Ettrup, Anders; Mikkelsen, Jens D.; Lehel, Szabolcs; Madsen, Jacob; Nielsen, Elsebet O.; Palner, Mikael; Timmermann, Daniel B.; Peters, Dan; Knudsen, Gitte M. Journal of Nuclear Medicine (2011), 52(9), 1449-1456.

Assessment of alpha7 nicotinic acetylcholine receptor availability in juvenile pig brain with [18F]NS10743. Deuther-Conrad, Winnie; Fischer, Steffen; Hiller, Achim; Becker; Georg; Cumming, Paul; Xiong, Guoming; Funke, Uta: Sabri, Osama; Peters, Dan; Brust, Peter. European Journal of Nuclear Medicine and Molecular Imaging (2011), 38(8), 1541-1549.

 

Comprehensive list of publications:

In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats Francisco R. López-Picón1, Anna K. Kirjavainen, Sarita Forsback, Jatta S. Takkinen, Dan Peters, Merja Haaparanta-Solin, Olof Solin. Theranostics 2019; 9(1):11-19

 

Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET. Teodoro R, Scheunemann M, Wenzel B, Peters D, Deuther-Conrad W, Brust P. Bioorg Med Chem Lett. 2018 May 15;28(9):1471-1475.

 

18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation.

 Kirjavainen AK, Forsback S, López-Picón FR, Marjamäki P, Takkinen J, Haaparanta-Solin M, Peters D, Solin O. Nucl Med Biol. 2018 Jan, 56, 39-46.

 

A novel dopamine reuptake inhibitor, IPED2015 induces spontaneous erections through activation of dopamine receptors in rats. The Journal of Sexual Medicine, July 2018, Volume 15, Issue 7, Supplement 3, S136 S. Comerma-Steffensen, A. Kun, G. Munro, D. Peters, U. Simonsen

 

Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [(18)F]NS14490. Rötering S, Scheunemann M, Günther R, Löser R, Hiller A, Dan Peters, Brust P, Fischer S, Steinbach J. Appl Radiat Isot. 2016 Aug;114: 57-62.

 

[¹¹C]NS9531, [¹¹C]NS9762 and [¹¹C]NS6417, specific SERT tracers: pre-clinical evaluation in pigs and optimization of synthesis conditions using [¹¹C]methyl triflate. Dam JH, Bender D, Peters D, Någren K. Nucl Med Biol. 2016 Jan;43(1):42-51.

 

 A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [18F]NS10743 Rodrigo Teodoro, Barbara Wenzel, Arata Oh-Nishi, Steffen Fischer, Dan Peters, Tetsuya Suhara, Winnie Deuther-Conrad and Peter Brust. Applied Radiation and Isotopes Volume 95, January 2015, Pages 76–84

 

Promising PET Tracer for Imaging of α₇ Nicotinic Acetylcholine Receptors in the Brain: Design,Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand. Teodoro R,  Scheunemann M, Deuther-Conrad W, Wenzel B, Fasoli FM, Gotti C, Kranz M, Donat CK, Patt M, Hillmer A, Zheng MQ, Peters D, Steinbach J, Sabri O, Huang Y, Brust P. Molecules. 2015 Oct 9;20(10):18387-421.

 

Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand. Magnussen JH, Ettrup A, Donat CK, Peters D, Pedersen MH, Knudsen GM, Mikkelsen JD. Eur J Pharmacol. 2015 Sep 5;762:35-41.

 

Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of chemotherapy-​induced neuropathic pain

By Hache, G.; Guiard, B. P.; Nguyen, T. H.; Quesseveur, G.; Gardier, A. M.; Peters, D.; Munro, G.; Coudore, F.

From European Journal of Pain (Oxford, United Kingdom) (2015), 19(3), 322-333.

 

Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. Ahring PK, Olsen JA, Nielsen EØ, Peters D, Pedersen MH, Rohde LA, Kastrup JS, Shahsavar A, Indurthi DC, Chebib M, Gajhede M, Balle T. Neuropharmacology. 2015 May;92:135-45.

 

A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [18F]NS10743. Teodoro R, Wenzel B, Oh-Nishi A, Fischer S, Peters D, Suhara T, Deuther-Conrad W, Brust P. Appl Radiat Isot. 2014 Oct 8;95C:76-84.

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [(18)F]NS14490. Rötering S, Deuther-Conrad W, Cumming P, Donat CK, Scheunemann M, Fischer S, Xiong G, Steinbach J, Peters D, Sabri O, Bucerius J, Brust P. EJNMMI Res. 2014 Aug 5;4:43.

[11C]NS8880, a promising PET radiotracer targeting the norepinephrine transporter. Vase KH, Peters D, Nielsen EØ, Alstrup AK, Bender D. Nucl Med Biol. 2014 Oct;41(9):758-64. doi: 10.1016/j.nucmedbio.2014.06.004. Epub 2014 Jun 25.

Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. Olsen JA, Kastrup JS, Peters D, Gajhede M, Balle T, Ahring PK. J Biol Chem. 2013 Dec 13;288(50):35997-6006.

 

Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Rasmussen AH, Strøbæk D, Dyhring T, Jensen ML, Peters D, Grunnet M, Timmermann DB, Ahring PK. Brain Res. (2014) Jan 13;1542:1-11.

 

Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. Olsen JA, Kastrup JS, Peters D, Gajhede M, Balle T, Ahring PK. J Biol Chem. (2013) Dec 13; 288(50):35997-6006.

 

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. Krintel C, Harpsøe K, Zachariassen LG, Peters D, Frydenvang K, Pickering DS, Gajhede M, Kastrup JS. Acta Crystallogr D Biol Crystallogr. (2013) Sep;69(Pt 9):1645-52.

 

A combined α7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances.

Andreasen JT, Redrobe JP, Nielsen EØ, Christensen JK, Olsen GM, Peters D.Neuropharmacology. (2013) Oct;73:183-91.

 

Radiosynthesis and first evaluation in mice of [18F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. Roetering, Sven; Scheunemann, Matthias; Fischer, Steffen; Hiller, Achim; Peters, Dan; Deuther-Conrad, Winnie; Brust, Peter. Bioorganic & Medicinal Chemistry (2013), 21(9), 2635-2642.

 

 Molecular determinants of subtype-selective efficacies of cytisine and the novel compd. NS3861 at heteromeric nicotinic acetylcholine receptors. Harpsoee, Kasper; Hald, Helle; Timmermann, Daniel B.; Jensen, Marianne L.; Dyhring, Tino; Nielsen, Elsebet Oe.; Peters, Dan; Balle, Thomas; Gajhede, Michael; Kastrup, Jette S.; et al. From Journal of Biological Chemistry (2013), 288(4), 2559-2570.

 

Synthesis of 10-methyl-8,10-diazabicyclo[4.3.1]decane as a new building block for nicotinic modulators, Osvaldas Paliulis, Dan Peters, Wolfgang Holzer and Algirdas Šačkus, ARKIVOC 2013 (iv) 240-250.

 

 Development of radioligands for the imaging of a 7 nicotinic acetylcholine receptors with positron emission tomography. Brust, Peter; Peters, Dan; Deuther-Conrad, Winnie.    Research Site Leipzig,  Helmholtz-Zentrum Dresden - Rossendorf,  Leipzig, Germany. Current Drug Targets (2012),  13(5),  594-601. 

 

 Enantiomerically pure (1S,5R) and racemic 3-(1-benzothiophen-2-yl)-8-azoniabicyclo[3.2.1]oct-2-ene acetate. Frostrup, Brian; Peters, Dan; Bond, Andrew D.    NeuroSearch A/S, Pederstrupvej 93,  Ballerup,  Den. Acta Crystallographica, Section C: Crystal Structure Communications  (2012),  C68(8),  o298-o301. 

 

 Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine a 4b 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED.      Rohde, Line Aagot Hede; Ahring, Philip Kiaer; Jensen, Marianne Lerbech; Nielsen, Elsebet Ostergaard; Peters, Dan; Helgstrand, Charlotte; Krintel, Christian; Harpsoe, Kasper; Gajhede, Michael; Kastrup, Jette Sandholm; Balle, Thomas.    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences,  University of Copenhagen,  Copenhagen,  Den.    Journal of Biological Chemistry  (2012),  287(6),  4248-4259. 

 

 Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test.      Andreasen, Jesper T.; Nielsen, Elsebet Oe.; Christensen, Jeppe K.; Olsen, Gunnar M.; Peters, Dan; Mirza, Naheed R.; Redrobe, John P.    Department of Affective Disorders,  NeuroSearch A/S,  Ballerup,  Den.    Journal of Psychopharmacology (London, United Kingdom)  (2011),  25(10),  1347-1356. 

 

 11C-NS14492 as a novel PET radioligand for imaging cerebral a 7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements.      Ettrup, Anders; Mikkelsen, Jens D.; Lehel, Szabolcs; Madsen, Jacob; Nielsen, Elsebet O.; Palner, Mikael; Timmermann, Daniel B.; Peters, Dan; Knudsen, Gitte M.    Neurobiology Research Unit,  Copenhagen University Hospital,  Copenhagen,  Den.    Journal of Nuclear Medicine  (2011),  52(9),  1449-1456.

 

 A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.      Thorsen, Thor S.; Madsen, Kenneth L.; Dyhring, Tino; Bach, Anders; Peters, Dan; Stroemgaard, Kristian; Roenn, Lars Christian B.; Gether, Ulrik.    Molecular Neuropharmacology Group, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, The Panum Institute,  University of Copenhagen,  Copenhagen,  Den.    Combinatorial Chemistry & High Throughput Screening  (2011),  14(7),  590-600. 

 

 Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.      Harpsoee, Kasper; Ahring, Philip K.; Christensen, Jeppe K.; Jensen, Marianne L.; Peters, Dan; Balle, Thomas.    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences,  University of Copenhagen,  Copenhagen,  Den.    Journal of Neuroscience  (2011),  31(30),  10759-10766. 

 

 Assessment of a 7 nicotinic acetylcholine receptor availability in juvenile pig brain with [18F]NS10743.      Deuther-Conrad, Winnie; Fischer, Steffen; Hiller, Achim; Becker, Georg; Cumming, Paul; Xiong, Guoming; Funke, Uta; Sabri, Osama; Peters, Dan; Brust, Peter.    Institute of Radiopharmacy,  Helmholtz-Zentrum Dresden-Rossendorf,  Leipzig,  Germany.    European Journal of Nuclear Medicine and Molecular Imaging  (2011),  38(8),  1541-1549. 

 

 Stereoselective Synthesis of Monoamine Reuptake Inhibitor NS9544 Acetate.      Malmgren, Haakan; Cotton, Hanna; Frostrup, Brian; Jones, David Spencer; Loke, Marie-Louise; Peters, Dan; Schultz, Sara; Soelver, Ellen; Thomsen, Tove; Wennerberg, Johan.    R&D,  DuPont Chemoswed,  Malmoe,  Swed.    Organic Process Research & Development  (2011),  15(2),  408-412. 

 

 In vitro pharmacological characterization of a novel selective a 7 neuronal nicotinic acetylcholine receptor agonist ABT-107.      Malysz, John; Anderson, David J.; Gronlien, Jens H.; Ji, Jianguo; Bunnelle, William H.; Hakerud, Monika; Thorin-Hagene, Kirten; Ween, Hilde; Helfrich, Rosalind; Hu, Min; Gubbins, Earl; Gopalakrishnan, Sujatha; Puttfarcken, Pamela S.; Briggs, Clark A.; Li, Jinhe; Meyer, Michael D.; Dyhring, Tino; Ahring, Philip K.; Nielsen, Elsebet O.; Peters, Dan; Timmermann, Daniel B.; Gopalakrishnan, Murali.    Neuroscience Research, Global Pharmaceutical Research and Development,  Abbott,  Abbott Park,  IL,  USA.    Journal of Pharmacology and Experimental Therapeutics  (2010),  334(3),  863-874.

 

 Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel a 7 neuronal nicotinic receptor (NNR) ligands.      Li, Tao; Bunnelle, William H.; Ryther, Keith B.; Anderson, David J.; Malysz, John; Helfrich, Rosalind; Gronlien, Jens H.; Hakerud, Monika; Peters, Dan; Schrimpf, Michael R.; Gopalakrishnan, Murali; Ji, Jianguo.    Neuroscience Research, GPRD, Dept. R4DE,  Abbott,  Abbott Park,  IL,  USA.    Bioorganic & Medicinal Chemistry Letters  (2010),  20(12),  3636-3639.

 

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.      Thorsen, Thor S.; Madsen, Kenneth L.; Rebola, Nelson; Rathje, Mette; Anggono, Victor; Bach, Anders; Moreira, Irina S.; Stuhr-Hansen, Nicolai; Dyhring, Tino; Peters, Dan; Beuming, Thijs; Huganir, Richard; Weinstein, Harel; Mulle, Christophe; Stromgaard, Kristian; Ronn, Lars Christian B.; Gether, Ulrik.    Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute,  University of Copenhagen,  Copenhagen,  Den.    Proceedings of the National Academy of Sciences of the United States of America  (2010),  107(1),  413-418, S413/1-S413/10.

 

 Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.      Thorsen, Thor S.; Madsen, Kenneth L.; Rebola, Nelson; Rathje, Mette; Anggono, Victor; Bach, Anders; Moreira, Irina S.; Stuhr-Hansen, Nicolai; Dyhring, Tino; Peters, Dan; Beuming, Thijs; Huganir, Richard; Weinstein, Harel; Mulle, Christophe; Stroemgaard, Kristian; Roenn, Lars Christian B.; Gether, Ulrik.    Molecular Neuropharmacology Group and Center for Pharmacogenomic, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen,  Copenhagen,  Den.    Proceedings of the National Academy of Sciences of the United States of America, Early Edition  (2009),   (Dec. 14 2009),  1-6.

 

 Role of channel activation in cognitive enhancement mediated by a 7 nicotinic acetylcholine receptors.      Briggs, Clark A.; Gronlien, Jens Halvard; Curzon, Peter; Timmermann, Daniel B.; Ween, Hilde; Thorin-Hagene, Kirsten; Kerr, Paige; Anderson, David J.; Malysz, John; Dyhring, Tino; Olsen, Gunnar M.; Peters, Dan; Bunnelle, William H.; Gopalakrishnan, Murali.    Neuroscience Research,  Abbott Laboratories,  Abbott Park,  IL,  USA.    British Journal of Pharmacology  (2009),  158(6),  1486-1494. 

 

 Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either a 4b 2 or a 7-selective nicotinic acetylcholine receptor (nAChR) ligands. substitutions that switch subtype selectivity.      Bunnelle, William H.; Tietje, Karin R.; Frost, Jennifer M.; Peters, Dan; Ji, Jianguo; Li, Tao; Scanio, Marc J. C.; Shi, Lei; Anderson, David J.; Dyhring, Tino; Gronlien, Jens H.; Ween, Hilde; Thorin-Hagene, Kirsten; Meyer, Michael D.    Neuroscience Research, Department R47W,  Abbott Laboratories,  Abbott Park,  IL,  USA.    Journal of Medicinal Chemistry  (2009),  52(14),  4126-4141. 

 

 Molecular imaging of a 7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743.      Deuther-Conrad, Winnie; Fischer, Steffen; Hiller, Achim; Ostergaard Nielsen, Elsebet; Brunicardi Timmermann, Daniel; Steinbach, Joerg; Sabri, Osama; Peters, Dan; Brust, Peter.    Institute of Interdisciplinary Isotope Research, Leipzig, Germany.    European Journal of Nuclear Medicine and Molecular Imaging (2009), 36(5),  791-800.

 

 Complementary Three-Dimensional Quantitative Structure-Activity Relationship Modeling of Binding Affinity and Functional Potency: A Study on a 4b 2 Nicotinic Ligands. Tosco, Paolo; Ahring, Philip K.; Dyhring, Tino; Peters, Dan; Harpsoe, Kasper; Liljefors, Tommy; Balle, Thomas.    Department of Drug Science and Technology, University of Turin, Turin,Italy. Journal of Medicinal Chemistry (2009),  52(8),  2311-2316. 

 

a 7 Nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice.      Redrobe, John P.; Nielsen, Elsebet O.; Christensen, Jeppe K.; Peters, Dan; Timmermann, Daniel B.; Olsen, Gunnar M.    Department of Affective Disorders,  NeuroSearch A/S,  Ballerup,  Den.    European Journal of Pharmacology (2009),  602(1),  58-65. 

 

 Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity.     Joergensen, Susanne; Nielsen, Elsebet Oestergaard; Peters, Dan; Dyhring, Tino.    Drug Discovery,  NeuroSearch A/S,  Ballerup,  Den.    Journal of Neuroscience Methods  (2008),  169(1),  168-176. 

 

 The novel compound (± )-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined m -opioid receptor agonist and monoamine reuptake inhibitor tramadol.      Munro, Gordon; Baek, Camilla Ae.; Erichsen, Helle K.; Nielsen, Alexander N.; Nielsen, Elsebet O.; Scheel-Kruger, Jorgen; Weikop, Pia; Peters, Dan.    NeuroSearch A/S,  Ballerup,  Den.    Neuropharmacology  (2008),  54(2),  331-343. 

 

Synthesis and Structure-​Activity Relationship Studies of 2-​(N-​Substituted)​-​aminobenzimidazoles as Potent Negative Gating Modulators of Small Conductance Ca2+-​Activated K+ Channels

By Sorensen, Ulrik S.; Strobaek, Dorte; Christophersen, Palle; Hougaard, Charlotte; Jensen, Marianne L.; Nielsen, Elsebet O.; Peters, Dan; Teuber, Lene

From Journal of Medicinal Chemistry (2008), 51(23), 7625-7634.

 

 An allosteric modulator of the a 7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.      Timmermann, Daniel B.; Groenlien, Jens Halvard; Kohlhaas, Kathy L.; Nielsen, Elsebet Oe.; Dam, Eva; Joergensen, Tino D.; Ahring, Philip K.; Peters, Dan; Holst, Dorte; Chrsitensen, Jeppe K.; Malysz, John; Briggs, Clark A.; Gopalakrishnan, Murali; Olsen, Gunnar M.    NeuroSearch A/S,  Ballerup,  Den.    Journal of Pharmacology and Experimental Therapeutics  (2007),  323(1),  294-307.

 

Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface.      Harpsoe, Kasper; Varming, Thomas; Gouliaev, Alex Haahr; Peters, Dan; Liljefors, Tommy.    Department of Medicinal Chemistry,  The Danish University of Pharmaceutical Sciences,  Copenhagen,  Den.    Journal of Molecular Graphics & Modelling  (2007),  26(1),  213-225.

 

 Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics.     Hansen, Henrik H.; Timmermann, Daniel B.; Peters, Dan; Walters, Carrie; Damaj, M. Imad; Mikkelsen, Jens D.    Dep. Translational Neurobiology,  NeuroSearch A/S,  Ballerup,  Den.    Journal of Neuroscience Research  (2007),  85(8),  1810-1818.

 

 Improved synthesis of 8-methyl-3,8-diazabicyclo[3.2.1]octane.      Paliulis, Osvaldas; Peters, Dan; Miknius, Linas; Sackus, Algirdas.    Institute of Synthetic Chemistry,  Kaunas University of Technology,  Kaunas,  Lithuania.    Organic Preparations and Procedures International  (2006),  Volume Date 2007,  39(1),  86-90. 

 

 New Ligands with Affinity for the a 4b 2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling.     Audouze, Karine; Oestergaard Nielsen, Elsebet; Olsen, Gunnar M.; Ahring, Philip; Jorgensen, Tino Dyhring; Peters, Dan; Liljefors, Tommy; Balle, Thomas.    NeuroSearch A/S,  Ballerup,  Den.    Journal of Medicinal Chemistry  (2006),  49(11),  3159-3171. 

 

 Solvent-free Heck-Jeffery reactions under ball-milling conditions applied to the synthesis of unnatural amino acids precursors and indoles.     Tullberg, Erik; Schacher, Felix; Peters, Dan; Frejd, Torbjoern.    Department of Organic Chemistry 1, Lund University,  Lund,  Swed.    Synthesis  (2006),   (7),  1183-1189. 

 

 Bioisosteric Modifications of 2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5.      Valgeirsson, Jon; Nielsen, Elsebet Oe.; Peters, Dan; Mathiesen, Claus; Kristensen, Anders S.; Madsen, Ulf.    Department of Medicinal Chemistry and Department of Pharmacology,  The Danish University of Pharmaceutical Sciences,  Copenhagen,  Den.    Journal of Medicinal Chemistry  (2004),  47(27),  6948-6957. 

 

The Heck reaction under ball-milling conditions.      Tullberg, Erik; Peters, Dan; Frejd, Torbjoern.    Department of Organic and Bioorganic Chemistry 1,  Lund University,  Lund,  Swed.    Journal of Organometallic Chemistry  (2004),  689(23),  3778-3781.

 

 New Series of Morpholine and 1,4-Oxazepane Derivatives as Dopamine D4 Receptor Ligands: Synthesis and 3D-QSAR Model.      Audouze, Karine; Nielsen, Elsebet Oestergaard; Peters, Dan.    NeuroSearch A/S,  Ballerup,  Den.    Journal of Medicinal Chemistry  (2004),  47(12),  3089-3104. 

 

 2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5.      Valgeirsson, Jon; Nielsen, Elsebet Oe.; Peters, Dan; Varming, Thomas; Mathiesen, Claus; Kristensen, Anders S.; Madsen, Ulf.    Departments of Medicinal Chemistry and Pharmacology,  The Danish University of Pharmaceutical Sciences,  Copenhagen,  Den.    Journal of Medicinal Chemistry  (2003),  46(26),  5834-5843. 

 

 Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.      Lademann, Ulrik; Cain, Kelvin; Gyrd-Hansen, Mads; Brown, David; Peters, Dan; Jaeaettelae, Marja.    Apoptosis Laboratory, Institute of Cancer Biology,  Danish Cancer Society,  Copenhagen,  Den.    Molecular and Cellular Biology  (2003),  23(21),  7829-7837.  Publisher: American Society for Microbiology,  CODEN: MCEBD4  ISSN: 0270-7306.  Journal  written in English.    CAN 140:53358    AN 2003:857360    CAPLUS   (Copyright (C) 2012 ACS on SciFinder (R))   

 

 Synthesis of the serotonin transporter ligand (± )-10-methyl 3-[6-nitro-(2-quinolinyl)]-3,10-diazabicyclo-[4.3.1]-decane ([11C-methyl]NS 2495) and first in vivo results.      Audrain, Helene; Bender, Dirk; Scheel-Krueger, Jorgen; Nielsen, Elsebet O.; Olsen, Gunnar M.; Peters, Dan; Cumming, Paul.    PET Center,  Aarhus University Hospital,  Aarhus C,  Den.    Journal of Labelled Compounds & Radiopharmaceuticals  (2003),  46(9),  873-882. 

 

 Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists.      Mirza, Naheed R.; Peters, Dan; Sparks, Robin G.    Departments of Pharmacology, Medicinal Chemistry & Pre-Clinical Development,  NeuroSearch A/S,  Ballerup,  Den.    CNS Drug Reviews  (2003),  9(2),  159-186. 

 

 [11C]-NS 4194 versus [11C]-DASB for PET imaging of serotonin transporters in living porcine brain.      Jensen, Svend B.; Smith, Donald F.; Bender, Dirk; Jakobsen, Steen; Peters, Dan; Nielsen, Elsebet O.; Olsen, Gunnar M.; Scheel-Krueger, Jorgen; Wilson, Alan; Cumming, Paul.    PET Center,  Aarhus University Hospital,  Aarhus,  Den.    Synapse (New York, NY, United States)  (2003),  49(3),  170-177.

 

 New class of iGluR5 selective glutamate antagonists.      Valgeirsson, Jon; Peters, Dan; Madsen, Ulf; Nielsen, Elsebet O.    Department of Medicinal Chemistry, The Royal Danish School of Pharmacy,  2100 Copenhagen,  Den.    Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003  (2003),    MEDI-198.  Publisher: American Chemical Society,  Washington, D. C. 

 

 Bioisosteric modification of iGluR5 selective glutamate antagonists.      Valgeirsson, Jon; Peters, Dan; Madsen, Ulf; Nielsen, Elsebet O.    Department of Medicinal Chemistry,  The Royal Danish School of Pharmacy,  2100 Copenhagen,  Den.    Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003  (2003),   MEDI-197.  Publisher: American Chemical Society, Washington.

 

 Synthesis of (± )-3-(6-nitro-2-quinolinyl)-[9-methyl-11C]-3,9-diazabicyclo[4.2.1]nonane ([11C-methyl]NS 4194).      Jensen, Svend B.; Bender, Dirk; Smith, Donald F.; Scheel-Kruger, Jorgen; Nielsen, Elsebet O.; Olsen, Gunnar M.; Peters, Dan; Gjedde, Albert.    PET Center,  Aarhus University Hospital,  Aarhus,  Den.    Journal of Labelled Compounds & Radiopharmaceuticals  (2002),  45(3),  181-189. 

 

 NS 1231, a novel compound with neurotrophic-like effects in vitro and in vivo.      Dago, Lone; Bonde, Christian; Peters, Dan; Moller, Arne; Bomholt, Signe Farso; Hartz, Barbara P.; Meyer, Morten; Drejer, Jorgen; Gronborg, Mette.    NsGene,  Ballerup,  Den.    Journal of Neurochemistry  (2002),  81(1),  17-24.

 

Synthesis and evaluation of racemic [11C]NS2456 and itsenantiomersas selective serotonin reuptake radiotracers for PET, D.F. Smith, D. Bender, K. Marthi, P. Cumming, S.B. Hansen, D. Peters, E. Ostergaard Nielsen, J. Scheel-Krüger, A. Gjedde. Nuclear Medicine and Biology 28 (2001) 265-270.

 

 NS-417, a novel compound with neurotrophic-like effects.      Dago, Lone; Peters, Dan; Meyer, Morten; Hartz, Barbara; Kruse, Vibeke; Drejer, Jorgen; Gronborg, Mette. NeuroSearch,  Ballerup,  Den.    Neurochemical Research  (2002),  27(1/2),  107-111.

 

 Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis.      Nielsen, Simon Feldbk; Nielsen, Elsebet Ostergaard; Olsen, Gunnar M.; Liljefors, Tommy; Peters, Dan.    NeuroSearch A/S,  Ballerup,  Den.    Journal of Medicinal Chemistry  (2000),  43(11),  2217-2226. 

 

 The Suzuki reaction under solvent-free conditions.      Nielsen, Simon Feldbaek; Peters, Dan; Axelsson, Oskar.    NeuroSearch A/S,  Ballerup,  Den.    Synthetic Communications  (2000),  30(19),  3501-3509. 

 

 Neuroprotection by a novel compound, NS521.      Gronborg, Mette; Johansen, Teit E.; Peters, Dan; Ahring, Philip K.; Drejer, Jorgen; Moller, Arne; Jensen, Leif H.    NeuroSearch A/S,  Glostrup,  Den.    Journal of Pharmacology and Experimental Therapeutics  (1999),  290(1),  348-353. 

 

 The nucleophilic ring-opening of N-benzylquinuclidinium bromide.      Axelsson, Oskar; Peters, Dan.    NeuroSearch A/S,  Glostrup,  Den.    Journal of Heterocyclic Chemistry  (1997),  34(2),  461-463. 

 

 Synthesis and biological activity of the neuronal calcium channel blocker 2-amino-1-(2,5-dimethoxyphenyl)-5-trifluoromethyl benzimidazole (NS-649).      Varming, Thomas; Christophersen, Palle; Moeller, Arne; Peters, Dan; Axelsson, Oskar; Nielsen, Elsebert Oe.    NeuroSearch,  Glostrup,  Den.    Bioorganic & Medicinal Chemistry Letters  (1996),  6(3),  245-8.

 

 Pharmacological profile and anti-ischemic properties of the Ca2+-channel blocker NS-638.      Moeller, Arne; Christophersen, Palle; Drejer, Joergen; Axelsson, Oskar; Peters, Dan; Jensen, Leif H.; Nielsen, Elsebet Oe.    NeuroSearch,  Glostrup,  Den.    Neurological Research  (1995),  17(5),  353-60. 

 

 One-pot synthesis of 4-[2-(3,4-dichlorophenoxy)ethyl]-1-pentylpiperidine hydrochloride (SB 201823-A).      Axelsson, Oskar; Peters, Dan.    NeuroSearch A/S,  Glostrup,  Den.    Organic Preparations and Procedures International  (1995),  27(5),  571-2. 

 

 Synthesis and antiviral activity of various 5-substituted 2'-deoxyuridines and -cytidines.      Peters, Dan; Hoernfeldt, Anna Britta; Gronowitz, Salo; Johansson, Nils Gunnar.    Chem. Cent.,  Lund,  Swed.    Nucleosides & Nucleotides  (1992),  11(6),  1151-73.

 

 Synthesis of various 5-substituted uracils

Peters, Dan; Hoernfeldt, Anna Britta; Gronowitz, Salo.    Chem. Cent.,  Univ. Lund,  Lund,  Swed.    Journal of Heterocyclic Chemistry  (1991),  28(8),  2079. 

 

 Synthesis of various 5-aryl-substituted cytosines.      Peters, Dan; Hoernfeldt, Anna Britta; Gronowitz, Salo.    Chem. Cent.,  Lund,  Swed.    Journal of Heterocyclic Chemistry  (1991),  28(6),  1613-17. 

 

 Synthesis of 5-cyclopropyluracil and 5-cyclopropylcytosine by the palladium(0)-catalyzed coupling reaction.      Peters, Dan; Hoernfeldt, Anna Britta; Gronowitz, Salo.    Chem. Cent.,  Lund,  Swed.    Journal of Heterocyclic Chemistry  (1991),  28(6),  1629-31. 

 

 Synthesis of various 5-substituted 2'-deoxy-3',5'-di-O-acetyluridines.      Peters, Dan; Hoernfeldt, Anna Britta; Gronowitz, Salo; Johansson, Nils Gunnar.    Chem. Cent.,  Lund,  Swed.    Journal of Heterocyclic Chemistry  (1991),  28(2),  529-31. 

 

 Synthesis of various 5-substituted uracils.      Peters, Dan; Hoernfeldt, Anna Britta; Gronowitz, Salo.    Chem. Cent.,  Univ. Lund,  Lund,  Swed.    Journal of Heterocyclic Chemistry  (1990),  27(7),  2165-73.     

 

 Convenient synthesis of various terheterocyclic compounds by palladium(0)-catalyzed coupling reactions.      Gronowitz, Salo; Peters, Dan.    Chem. Cent.,  Lund,  Swed.    Heterocycles  (1990),  30(1, Spec. Issue),  645-58. 

 

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